May 25, 2004
Justin
D. Oh-Lee, PhD
Assistant
Professor
Co-Director,
Brain Research and Integrative Neuroscience Center
Psychology
Department
Central Michigan University
Psychology Dept.
Sloan Hall 224
Mount Pleasant, MI 48859
Office: Sloan 224; (989) 774-6492; Fax (989) 774-2553
E-mail: oh1jd@cmich.edu; ohju@ninds.nih.gov
Education
1999 – 2001 Research Fellow, Clinical Pharmacology section,Experimental
Therapeutics Branch, NINDS, NIH, Bethesda, MD
1995 – 1999 Postdoctoral IRTA Fellow, Clinical Pharmacology section,
Experimental
Therapeutics Branch, NINDS, NIH,
Bethesda, MD
1991 - 1995 Ph.D. in Psychology (Behavioral Neuroscience), University of
California, Los Angeles (UCLA),
CA.
1989 - 1991 M.A. in Psychology (Physiological Psychology), UCLA, Los
Angeles, CA.
1982 - 1986
B.A. in Chemistry,Colorado College, Colorado
Springs, CO.
1979 - 1982
Westminster High
School, Westminster, CO
Publications and Presentations
Publications
Bibbiani F and Oh JD,
Petzer JP, Castagnoli N, Chen J-F, Schwarzchild MA, and Chase TN. (2003) A2A
antagonist prevents dopamine agonist-induced motor complications in animal
models of PD. Experimental Neurology, in press.
Chase
TN, Bibbiani F, Bara-Jimez W, Dimitrova T, Oh JD. (2003) Translating A2a
antagonist KW-6002 from animal models to parkinsonian patients. Neurology,
in press
Oh
JD, Chartisathian K, Ahmed SM, and Chase TN. (2003) Cyclic AMP responsive
element binding protein (CREB) Phosphorylation and Persistent Expression of
Levodopa-induced Response Alterations in Parkinsonian Rats. Journal of
Neuroscience Research, 72, 768-780.
Oh JD, Geller AI, Zhang GR, Chase TN. (2003) Gene transfer
of constitutively active protein kinase C into striatal neurons accelerates
onset of levodopa-induced motor response alterations in parkinsonian rats. Brain
Research, 971(1),
18-30.
Chase TN, Bibbiani F, Oh JD. (2003) Striatal Glutamatergic Mechanisms and Extrapyramidal
Movement Disorders. Neurotoxicity
Research, 5(1-2), 139-146.
Oh
JD, PhD,
Francesco Bibbiani, MD, Thomas N. Chase, MD. (2002) Quetiapine Attenuates
Levodopa-induced Motor Complications in Rodent and Primate Parkinsonian Models. Experimental
Neurology 177(2), 557-564.
Metman LV and Oh
JD. (2002) Dyskinesias in
Parkinson’s Disease; Ionotrophic Glutamate Receptors as Therapeutic
Targets (Ed: Lodge D.; Danysz W.; Parsons CG), pp. 205-225, F.P. Graham
Publishing Co., Johnson City, Tennessee.
Oh JD
and Chase TN (2002) Glutamate-mediated striatal dysregulation and pathogenesis
of Parkinsonian motor response complications, Amino
Acids, 23, 133-139.
Bibbiani F; Oh JD; Chase TN. (2002) Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology, Vol 58, Iss 7, pp A373-A37
Chase TN; Konitsiotis S; Oh JD. (2001) Striatal molecular mechanisms and motor dysfunction in Parkinson's disease. Advances In Neurology. PARKINSON'S DISEASE, Vol 86, pp 355-360
Bibbiani F, Oh JD, Chase TN, (2001) Serotonin
5-HT1A agonist, sarizotan, attenuates levodopa-induced motor complications in
rodent and primate parkinsonian models, Neurology, 57, 1829-1834.
Zhong LT, Manzi A, Skowronski E, Notterpek L,
Fluharty AL, Faull KF, Masada I, Rabizadeh S, Varsanyi-Nagy M, Ruan YL, Oh
JD, Butcher LL, Bredesen DE, (2001), A monoclonal antibody that induces
neuronal apoptosis binds a metastasis marker, Cancer
Research, 61(15), 5741-5748.
Chase
TN, Konitsiotis S and Oh JD, (2000),
Striatal Molecular Mechanisms and Motor Dysfunction in Parkinson’s Disease, In Parkinson’s disease:
Advances in Neurology, Vol. 86, (Ed. Calne D and Calne S), Lippincott
Williams & Wilkins.
Chase
TN and Oh JD. (2000), Striatal
dopamine- and glutamate-mediated dysregulation in experimental parkinsonism, Trends
in
Neuroscience, 23, S86-S91.
Oh JD,
Chartisathian K, Chase TN and Butcher LL, (2000), Overexpression of neurotrophin
receptor p75 contributes to the excitotoxin-induced cholinergic cell death in
the rat basal forebrain, Brain
Research, 853, 174-185.
Chase
TN, Oh JD and Konitsiotis S, (2000),
Antiparkinsonian and antidyskinetic activity of drugs targeting central
glutamatergic mechanisms, Journal of
Neurology, 247, S36-S42.
Chase
TN and Oh JD, (2000), Striatal
mechanisms and pathogenesis of Parkinsonian signs motor complications, Ann. Neurology, 46, S122-S130.
Oh JD,
(1999), Regulation of striatal N-methyl-D-aspartate receptor (NMDAR) function by
phosphorylation of its subunits in parkinsonian rats, In Methods in Molecular Medicine-Parkinson’s
disease Methods and Protocols (Ed.
Mouradian M.), The Humana Press, Inc.
Oh JD,
Vaughan CL and Chase TN, (1999), Effect of dopamine denervation and dopamine
agonist administration on serine phosphorylation of striatal NMDA receptor
subunits, Brain Research, 821
(2), 433-442.
Chase
TN and Oh JD, (1998), Striatal
dopaminergic-glutamatergic system interactions: Contribution to Parkinson's
disease symptoms and levodopa response alterations In Interactive Monoaminergic Basis of
Brain Disorders (Eds:
Palomo T, Archer T, Beninger RJ), Cerebro Y Mente Foundation, Madrid.
Oh JD,
Russell D, Vaughan CL and Chase TN, (1998), Enhanced tyrosine phosphorylation of
striatal NMDA receptor subunits: Effects of dopaminergic denervation and
levodopa administration, Brain
Research, 813, 150-159.
Chase
TN, Oh JD and Blanchet PJ, (1998),
Neurostriatal mechanisms in Parkinson’s disease, Neurology, 51(Suppl 2), 30-35.
Oh JD,
Del Dotto P, and Chase TN, (1997), Protein kinase A inhibitor
attenuates levodopa-induced motor response alterations in the hemi-parkinsonian
rat, Neuroscience Letters,
228, 5-8.
Woolf
NJ and Oh JD, (1997), Thyroid hormone
action in rat brain from fetal to adult life. In Neuroendocrinology-Thyroid
hormone and Brain Maturation. (ed: Hendrich, C.E.), pp. 31-38, Research
Signpost, Trivandrum.
Oh JD,
Edwards RH and Woolf NJ, (1996), Choline Acetyltransferase mRNA Plasticity with
Pavlovian Conditioning, Experimental
Neurology, 140(1), 95-99.
Farris
TW, Butcher LL, Oh JD and Woolf NJ,
(1995), Trophic-factor modulation of cortical acetylcholinesterase reappearance
following transection of the medial cholinergic pathway in the adult rat, Experimental
Neurology, 131(2), 180-192.
Rabizadeh
S, Oh JD, Ord T, Butcher LL and Bredesen DE, (1993), Induction of apoptosis by
the low-affinity NGF receptor, Science,
261, 345-348.
Butcher
LL, Oh JD, Woolf NJ, (1993),
Cholinergic neurons identified by in-situ hybridization histochemistry, Progress
in Brain Research, 98, 1-8.
Farris
TW, Woolf NJ, Oh JD, Butcher LL,
(1993), Reinnervation of cerebral cortex following axotomy of the medial
cholinergic pathway in the adult rat brain: reestablishment of lamina pattern of
acetylcholinesterase activity, Experimental
Neurology, 121(1), 77-92.
Butcher
LL, Oh JD, Woolf NJ, (1992),
Organization of central cholinergic neurons revealed by combined in-situ
hybridization and
cholineacetyl-transferase immunohistochemistry, Neurochemistry
International, 21(3), 429-445.
Oh JD,
Woolf NJ, Roghani A, Edwards RH, Butcher LL, (1992), Cholinergic neurons in the
rat central nervous system demonstrated by in-situ hybridization of ChAT mRNA, Neuroscience,
47(4), 807-822.
Oh JD,
Butcher LL, Woolf NJ, (1991), Thyroid hormone modulates the development of the
cholinergic terminal fields in the rat forebrain: relation to nerve growth
factor receptor, Developmental Brain
Research, 59, 133-142.
Di
Patre PL, Oh JD, Simmons JM, Butcher
LL, (1990), Intrafimbrial colchicine produces
transient impairment of radial-arm maze performance correlated with morphologic
abnormalities of septohippocampal neurons expressing cholinergic markers and
nerve growth factor receptor. Brain
Research, 523, 316-320.
Presentation
Thyroid Hormones
After the
Postnatal Development
of the 68kD Neurofilament Protein in the Cerebral Cortex: an
Immunocytochemical Analysis. (1989),
NJ Woolf, JD Oh, and LL Butcher, Society for Neuroscience Abstracts 15
(2), 405.3.
Lesions of the Pedunculopontine Tegumental Nucleus
Produce Loss of Basal Forebrain Choline Acetyltransferase: Evidence for
Cholinergic Interactions. JD Oh, NJ
Woolf, and LL Butcher, Society for Neuroscience Abstracts (1989), 15(1),
311.11.
Immunostaining for Microtubule -Associated Proteins
(MAP-1,-2,-5) is decreased by Ibotenic Acid Lesions of the Cholinergic Basal
Forebrain. NJ Woolf, JD 0h, and LL
Butcher, Society for Neuroscience Abstracts (1990), 16(2), 434.17.
Localization of CHAT mRNA in the Rat Brain and Spinal
Cord. JD Oh, NJ Woolf, A Roghani,
RH Edwards, and LL Butcher. Society
for Neuroscience Abstracts (1991), 17(2), 519.7.
Excitotoxic Lesions of the Pedunculopontine
Tegumental Nucleus Impair Radial-Arm Maze Performance. LL Butcher, JD Oh, and C.
Cesarz, Society for Neuroscience Abstracts, (1992), 18(2), 480.3.
Radial-Arm Maze
Performance in Rats is
Impaired by Vesamicol [(-)-Trans-2-(4-Phenyldiperidine) Cyclohexanol], a Potent
Inhibitor of Acetylcholine Active Transport by Synaptic Vesicles.
JD Oh, S Bockenhauer, A Keller, SM Parson, GA Rogers, and LL Butcher,
Society for Neuroscience Abstracts, (1992), 18(2), 480.4.
Production and Analysis of Transgenic Mouse Lines
Overexpressing NGF in CNS. A
Roghani, T Farris, JD Oh, GD Ellison, LL Butcher, D. Hanahan, and RH Edwards,
Society for Neuroscience Abstracts, (1992), 18(2), 544.8.
Thyroid Hormones After the Time Course of Choline
acetyltransferase (ChAT) Expression During Postnatal Development in the
Forebrain Cholinergic System: A Non-radioactive In-Situ Hybridization of ChAT
mRNA. JD Oh, A Roghani, R Edwards, and LL Butcher, Society for Neuroscience
Abstracts, (1993), 19(2), 712.7.
Increased MAP-2 Immunohistochemistry Following
Pavlovian Conditioning in Auditory Cortex is Correlated with Increased MAP-2
Kinase and Protein Kinase C Immunohistochemistry, but levels of MAP-2 mRNA are
Unchanged. NJ Woolf, JD Oh, and RH Edwards, (1994), 20(1), 187.3.
Choline Acetyl transferase mRNA is Selectively Increased in Cells Projecting to Auditory
Cortex Following Pavlovian Conditioning to Tone. JD Oh, C Kuo, RH Edwards, and
NJ Woolf, Society for Neuroscience,
(1994), 20(1), 187.4.
Medial Septal Cells are Vulnerable
to Kainic Acid (KA), Quinolinic Acid (QA), Colchicine (COL), and
2,5-Hexanedione (2,5-HX): The Reversal Role of Nimodipine on KA and QA-induced
Neurotoxicity, JD Oh and TN Chase, Society for Neuroscience Abstracts, (1996),
22(3), 746.3.
Protein Kinase A Inhibitor Reverses Levodopa-Induced
Motor Response Alterations in the Hemi-Parkinsonian Rat.
JD Oh, PD Dotto, and TN Chase, Society for Neuroscience Abstracts, (1997),
23(2), 589.11.
Tyrosine Kinase Inhibitor Reverses Levodopa-Induced
Motor Response Alterations in the Hemi-Parkinsonian Rat. JD Oh and TN Chase,
Society for Neuroscience Abstracts, (1998), 24(1), 50.18.
Neurotrophin
Receptor P75 Meiates Excitotoxin Induced Cholinergic Neuronal Death in Rat Basal
Forebrain. JD Oh, K Chartisathian, and TN Chase, Society for Neuroscience
Abstracts, (1999), 25 (1) & The IBC's Eighth Annual Conference for AD
in Boston.
CREB
phosphorylation and the persistence of levodopa-induced motor response
alterations in parkinsonian rats. J.D. Oh; K. Chartisathian; C. Vaughn; T.N.
Chase, Clinical Pharmacology, NINDS-ETB, NIH, Bethesda, MD, USA, Society for
Neuroscience Abstracts, (2000), 26(1), 278.4.
Glutamate-mediated
striatal dysregulation and pathogenesis of Parkinsonian motor response
complications. J. D. Oh and T.N.
Chase, International Congress in Amino
Acids: Symposium in L-dopa induced motor response complications, (July, 2001),
Vienna, Austria.
Serotonin 5HT2A antagonist
attenuates levodopa-induced motor response alterations in rodent and primate
parkinsonian models J.D. Oh; F.
Bibbiani; F.M. Sarsoza; T.N. Chase, Society
for Neuroscience, November, (2001), San Diego, CA, USA.
Serotonin
5-HT1A agonist improves motor complications in rodent and primate parkinsonian
models. F. Bibbiani; J.D. Oh; T.N.
Chase, Society for Neuroscience
November, 2001, San Diego, CA, USA
Regulation
of phosphorylation state of striatal NMDA and AMPA receptor subunits following
dopaminergic denervation and chronic L-dopa administration.
I. Avila, JD Oh, B Razvi, C Smith, TN Chase, August 2002,
NINDS Summer Research Poster Presentation.
Serotonin
5-HT1A Agonist Improves Motor Complications in Rodent and Primate Parkinsonian
Models. Francesco Bibbiani, Justin D. Oh, Thomas N. Chase. American
Academy of Neurology, 2002. Denver, CO.
Receptor
Antagonist Prevents the Development of Dopamine Agonist-Induced Motor
Complications in Primate and Rodent Models of Parkinson's Disease. Bibbiani;
J.D. Oh; J.P. Petzer; N. Castagnoli, Jr; J.-F. Chen; M.A. Schwarzschild;
T.N. Chase. Translating Adenosine A2A Receptor Biology into Novel Therapies for
Parkinson's Disease, September 2002. Boston, MA.
A2A
Receptor Antagonist Prevents the Development of Dopamine Agonist-Induced Motor
Complications in Primate and Rodent Models of Parkinson's Disease. Bibbiani;
J.D. Oh; J.P. Petzer; N. Castagnoli, Jr; J.-F. Chen; M.A. Schwarzschild;
T.N. Chase. 2002 Movemet Disorder Society Meeting, Miami, FL.
Regulation
of phosphorylation state of striatal NMDA and AMPA receptor subunits following
dopaminergic denervation and chronic L-dopa administration. 2002, NINDS
Summer Research Poster Presentation.
Effects of CP-101,606 on
Levodopa-Induced Motor Response Symptoms in 6-OHDA Hemiparkinsonian Rats.
Student:Ryan H. Wessell; Faculty Advisor:Justin D. Oh-Lee, Ph.D.BRAIN Research
Laboratory, Central Michigan University (CMU), Mount Pleasant, MI 48859. 2003
Michigan Chapter SFN 34th Annual Meeting.
Dysfunctions in neurotrophin receptor p75 contributes to the NMDA-induced spatial memory deficit in mice. Student: Syed M. Ahmed; Faculty Advisor: Justin D. Oh-Lee, Ph.D.BRAIN Research Laboratory, Central Michigan University (CMU), Mt. Pleasant, MI 48859. 2003 Michigan Chapter SFN 34th Annual Meeting.
Professional Activities
American
Association for the Advancement of Science
American
Psychological Society
American Psychological Association
Society
for Philosophy and Psychology
National Institutes of Health, Asian & Pacific Islanders American
Organization
Directed Research and Creative Endeavors Exhibition
2002-2003 Directed Research
Spring 2002
Lindsay Barrett, Alexis Bowser, Christian Buhagiar, LeAnne
Forquer, &
Ryan Wessell
Fall 2002
Lindsay Barrett, Ryan Brown, Greta Klein, Jason Leiter, Amanda Leshk,
Brooke Naffziger, Jennie Patten, John Scherer
Spring 2003 Heather
Ferber, Jennifer Mosack, Daniel Nadeau, Brooke Naffziger, Teri
Schonedelmayer, Ami Miller, Katrina Jones, Mahlon Collins, Seneca Cotterman,
Andrew Eagle, Jen Basses, Christian Buhagiar, Chelsea Onifer, Ingrid Parrington,
Jefrey Burnell
Julie
McQuaide
The Effects of Unilateral QA Lesions of the Caudate Nucleus on Tactile
Sensory Perception in Rats
Divya
Unni
Effects of a Novel Substituted Pyrimidine in Reducing Age-Related
Deficits
Ryan Wessell:
Effects of CP-101,606 on parkinsonian motor symptoms in rodent
hemiparkinsonian model
Syed
M Ahmed: Effects of
chronic exposure to levodopa are regulated by the neuronal protein Cdk5 in
6-OHDA Hemiparkinsonian Rats.
Jennifer Basse:
Effects of 6-OHDA Lesions of the Dopaminergic Pathway on Discrimination
Conditioning in Animal Models of Parkinson’s Disease.
Christian Buhagiar:
Protein Kinase C (PKC), but not FYN, Transgenic Mice are Protected Against
Haloperidol-Induced Motor Dysfunction.
Jeff Burnell:
Chronic
Administration with Dopamine Antagonist Haloperidol Induces Motor Dysfunction in
Protein Kinase C (PKC) Transgenic Mice.
Seneca
Cotterman: Effects of 6-OHDA Lesions of the
Nigrostriatal Pathway and Chronic Levodopa Administration on Dopamineric
Receptor 4 Expression in Rats.
Andrew Eagle:
Effects
of 6-OHDA Lesions of the Medial Forebrain Bundles on a Spatial Discrimination
Conditioning in Rats
Amanda Leshk:
Effects of Adenosine Antagonist on a Conditioned Motor Task in an Animal Model
of Parkinson’s Disease.
Brooke N. Naffziger:
Effects of 6-OHDA Lesions of the Medial Forebrain Bundles and Chronic
Levodopa Treatment on Striatal Cholinergic Activity in Rats.
Teri Schondelmayer:
Effects of 6-OHDA Lesions of the Medial Forebrain Bundles on an Operantly
Conditioned Behavior in Rats.
1.
Syed M. Ahmed, Gary Dunbar, and Justin Oh-Lee. 2002. Relationship between
Neuronal Plasticity in the Hippocampus and Cognitive Performance in Aged Rats.
Student Creative Research and Endeavors Exhibition. Pg 76.
2.
Lindsay Barrett, Justin Oh-Lee, and Gary Dunbar. 2002. Motor Asymmetries
Following QA-induced Disruption of Cholinergic Basal Ganglia Function in Rats.
Student Creative Research and Endeavors Exhibition. Pg 76
3.
Jennifer Basse, David Laur, Gary L. Dunbar, and Justin Oh-Lee. 2002.
Effects of Dopamine Denervation and DARPP-32 Expression on Locomotor Activity in
Protein Kinase C Knock-Out Mice. Student Creative Research and Endeavors
Exhibition. Pg 77.
4.
Alexis Bowser, Stephanie Schoenjahn, Gary Dunbar, and Justin Oh-Lee.
2002. Correlation of Working and Reference Memory to QA-induced Cell Alterations
in Phosphorylated Cyclic-AMP Responsive Element Binding Protein (pCREB) in rats.
Student Creative Research and Endeavors Exhibition. Pg 78.
5.
Christian Buhagiar, Gia Patten, Gary L. Dunbar, and Justin Oh-Lee. 2002.
Motor Deficit following Dopamine Denervation in FYN Knockout Mice. Student
Creative Research and Endeavors Exhibition. Pg 78.
6.
Heather Ferber, Elizabeth Franas, Gary L. Dunbar, and Justin Oh-Lee.
2002. Use of Drag Test for Measuring Motor Impairments in a Rodent Model of
Huntington’s disease. Student Creative Research and Endeavors Exhibition. Pg
81.
7.
LeAnne Forquer, Gary Dunbar, and Justin Oh-Lee. 2002. The Behavioral
Effects of 6-OHDA Lesions on the Operant Conditioning of a Complex Motor Task in
Rats. Student Creative Research and Endeavors Exhibition. Pg 81.
8.
Timothy Gates, Justin Oh-Lee, and Gary Dunbar. 2002. A Novel Substituted
Pyrimidine Compound as Treatment for the Cognitive Impairment and Neuronal Loss
in a Rodent Model of Huntington’s Disease. Student Creative Research and
Endeavors Exhibition. Pg 82.
9.
Josh Hook, Steven Demny, Justin Oh-Lee and Gary Dunbar. 2002.
Sensorimotor Deficits as a Correlate to Cell Loss Following Unilateral
Intrastriatal Injections of Quinolinic Acid in Rats. Student Creative Research
and Endeavors Exhibition. Pg 83.
10.
Kelly J. Jackson, Justin Oh-Lee, and Gary Dunbar. 2002. Effects of
Chronic Intrastriatal Infusion of Quinolinic Acid on Striatal and Hippocampal
Volume. Student Creative Research and Endeavors Exhibition. Pg 84.
11.
Nichole Jaskiw, Jessica Love, Gary Dunbar, and Justin Oh-Lee. 2002. The
Relationship between Dopaminergic Innervation of the Neostriatum and Grip
Strength in Rats. Student Creative Research and Endeavors Exhibition. Pg 84.
12.
Amy Kuechenmeister, Kristen Franklin, Justin Oh-Lee, and Gary Dunbar.
2002. The effect of Quinolate-Induced Striatal Lesions on Postural Asymmetries
in Rodent Models of Huntington Disease. Student Creative Research and Endeavors
Exhibition. Pg 85.
13.
Rhonda McLean, Gary L. Dunbar, and Justin Oh-Lee. 2002. Differential
Changes in Kainic Acid Induced Hippocampal Cell Loss in Young and Aged Rats.
Student Creative Research and Endeavors Exhibition. Pg 86.
14.
Julie McQuaide, Justin Oh-Lee, and Gary Dunbar. 2002. The Effects of
Unilateral Quinolinic\ Acid Lesions of the Caudate Nucleus on Tactile Sensory
Perception in Rats. Student Creative Research and Endeavors Exhibition. Pg 86.
15.
Jeff Samyn, Justin Oh-Lee, and Gary Dunbar. 2002. Detection of Apoptosis
in the Quinolinic Acid Model of Huntington’s disease. Student Creative
Research and Endeavors Exhibition. Pg 87.
16.
John Scherer, Jeff Burnell, Gary L. Dunbar, and Justin Oh-Lee. 2002.
Effects of Unilateral Striatal Cell Loss on Spontaneous Motor Activity in Rats.
Student Creative Research and Endeavors Exhibition. Pg 89.
17.
Nicole Trail, Drew Sands, Justin Oh-Lee, and Gary Dunbar. 2002. The
Correlation of Apoptotic Neuronal Loss in the Neostriatum with Balance Beam
Performance in Rats. Student Creative Research and Endeavors Exhibition. Pg 91.
18.
Divya Unni, Justin Oh-Lee, and Gary Dunbar. 2002. A Novel Substituted
Pyrimidine Reduces Age-Related Cognitive Deficits. Student Creative Research and
Endeavors Exhibition. Pg 91.
19.
Stacey Watson, Amanda Leshk, Justin Oh-Lee, and Gary Dunbar. 2002. The
Relationship between Losses of CYO Activity in the Striatum with Alterations in
Gait Patterns in Rats. Student Creative Research and Endeavors Exhibition. Pg
92.
20.
Ryan Wessell, Gary Dunbar, and Justin Oh-Lee. 2002. Effects of 6-OHDA
Lesions of the Medial Forebrain Bundles on a Conditioned Motor Task in Rats.
Student Creative Research and Endeavors Exhibition. Pg 92.
Effects
of Adenosine Antagonist on a Conditioned Motor Task in an Animal Model of
Parkinson’s Disease
Authors:
Ryan Wessell, Amanda Leshk, Lindsay Barret, and Ryan Brown
Effects
of CP-101,606 on parkinsonian motor symptoms in rodent hemiparkinsonian model
Authors:
Ryan Wessell and Syed M. Ahmed
Overexpression of neurotrophin receptor p75 contributes to
the NMDA-induced neuronal death in mice.
Authors:
Syed M. Ahmed and Heather L. Ferber
Effects
of chronic exposure to levodopa are regulated by the neuronal protein Cdk5 in
6-OHDA Hemiparkinsonian Rats.
Authors: Syed M. Ahmed and Jacob M. McClean
Effects
of 6-OHDA Lesions of the Medial Forebrain Bundles and Chronic Levodopa Treatment
on Striatal Cholinergic Activity in Rats.
Author:
Brooke Naffziger
Behavioral
Consequences of Heterologous Bone Marrow Derived Stem Cell Transplants in a
Rodent Model Of Huntington's Disease
Authors:
Heather L. Ferber and Ingrid A. Parrington
Effects
of dopaminergic denervation by 6-OHDA on a Conditioned Complex Motor Behavior in
Rats
Author: Jason M. Leiter
Effects
of 6-OHDA Lesions of the Medial Forebrain Bundles on Discrimination Conditioning
in Rats
Authors: Jen Basse, Dan Nadeau, Chelsea Onifer
Protein
Kinase C (PKC), but not Fyn, Transgenic Mice are Protected Against Haloperidol-
Induced Motor Dysfunction
Authors: Jennie Patten, Jeff Burnell, Christian Buhagiar
Effects
of 6-OHDA Lesions of the Nigrostriatal Pathway and Chronic Levodapa
Administration on Dopaminergic Receptor 4 Expression in Rats.
Authors: Seneca R. Cotterman and Brooke N. Naffziger
Effects
of 6-OHDA Lesions of the Medial Forebrain Bundles on an Operantly Conditioned
Behavior in Rats
Authors:
Katrina Lynn Jones and Teri Lyn Schondelmayer
The Potential Therapeutic Effects of Behavioral
Intervention on Operantly Conditioned Motor Task in 6-OHDA Rats
Authors:
Ami Miller and Jen Mosack
Effects
of 6-OHDA Lesions of the Medial Forebrain Bundles on a Spatial Discrimination
Conditioning in Rats
Authors: Andrew Eagle,
Lindsey Holmes, and Mahlon Collins
Others
Research Experience
1984 – 1985
Participated in Honors Science Motivation Program
at Washington University, St.. Louis, MO.
1986 – 1987 Laboratory Assistant, at the department of
Toxicology/Biochemistry, University
of Southern California Medical Center, Los Angeles, CA.
1987 – 1989 Laboratory Associate, at the department of psychology,
physiological psychology, UCLA, Los Angeles, CA.
1989 – 1995 Graduate Student Research Associate at the department of
psychology behavioral neuroscience area, UCLA, Los Angeles,
CA.
1995 – 1999 IRTA Fellow, Clinical Pharmacology section at the Experimental
Therapeutics Branch, NINDS, NIH, Bethesda, MD.
1999 – 2001
Research Fellow, Clinical Pharmacology section,
Therapeutics Branch, NINDS, NIH, Bethesda, MD.
2001 – present
Assistant Professor, Psychology Department,
Central Michigan
University, MI